Radioactive 133-Xenon Gas-Filled Balloon to Prevent Restenosis

نویسندگان

  • Ron Waksman
  • Rosanna C. Chan
  • Yoram Vodovotz
چکیده

Background—Ionizing radiation administered intraluminally via catheter-based systems using solid and sources or liquid-filled balloons has shown reduction in the neointima formation after injury in the porcine model. We propose a novel system that uses a 133-Xenon (Xe) radioactive gas-filled balloon catheter system. Methods and Results—Overstretch balloon injury was performed in the coronary arteries of 33 domestic pigs. A novel Xe radioactive gas–filled balloon (3.5/45 mm) was positioned to overlap the injured segment with margins. After vacuum was obtained in the balloon catheter, 2.5 cc of Xe gas was injected to fill the balloon. Doses of 0, 7.5, 15, and 30 Gy were delivered to a distance of 0.25 mm from the balloon surface. The dwell time ranged from 1.0 to 4.0 minutes, depending on the dose. Localization of Xe in the balloon was verified by a camera. The average activity in a 3.5/45-mm balloon was measured at 67.7 12.1 mCi, and the total diffusion loss of the injected dose was 0.26% per minute of the injected dose. Bedside radiation exposure measured between 2 and 6 mR/h, and the shallow dose equivalent was calculated as 0.037 mrem per treatment. Histomorphometric analysis at 2 weeks showed inhibition of the intimal area (intimal area corrected for medial fracture length [IA/FL]) in the irradiated segments of 0.26 0.08 with 30 Gy, 0.07 0.24 with 15 Gy, and 0.12 0.89 with 7.5 Gy versus 0.76 0.08 with control P 0.001. Conclusions—Xe gas–filled balloon is feasible and effective in the reduction of neointima formation in the porcine model and safe for use in coronary arteries. (Circulation. 2002;106:725-729.)

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Radioactive 133-Xenon gas-filled balloon to prevent restenosis: dosimetry, efficacy, and safety considerations.

BACKGROUND Ionizing radiation administered intraluminally via catheter-based systems using solid beta and gamma sources or liquid-filled balloons has shown reduction in the neointima formation after injury in the porcine model. We propose a novel system that uses a 133-Xenon (133Xe) radioactive gas-filled balloon catheter system. METHODS AND RESULTS Overstretch balloon injury was performed in...

متن کامل

Dosimetry of 188Re and 186Re sources based on Monte Carlo calculations for endovascular brachytherapy after balloon angioplasty

Background: Recent pre-clinical and clinical studies indicate that irradiation in the dose range of 15 to 30 Gy can reduce rate of restenosis in patients who have undergone an angioplasty. The use of filled balloon with radioactive solution was proposed as one of the possible intravascular irradiation techniques. Materials and Methods: The Monte Carlo N-particle Transport Code (MCNP4b) was used...

متن کامل

A novel balloon angioplasty catheter impregnated with beta-particle emitting radioisotopes for vascular brachytherapy to prevent restenosis; first in vivo results.

BACKGROUND According to early clinical trials, vascular brachytherapy performed prior to or shortly after angioplasty is very effective in reducing restenosis rates. The purpose of this study was to investigate the effects of a novel radioactive catheter that allows simultaneous balloon angioplasty and beta-particle irradiation in the prevention of restenosis. MATERIAL AND METHODS The balloon...

متن کامل

Detection of (133)Xe from the Fukushima nuclear power plant in the upper troposphere above Germany.

After the accident in the Japanese Fukushima Dai-ichi nuclear power plant in March 2011 large amounts of radioactivity were released and distributed in the atmosphere. Among them were also radioactive noble gas isotopes which can be used as tracers to test global atmospheric circulation models. This work presents unique measurements of the radionuclide (133)Xe from Fukushima in the upper tropos...

متن کامل

Validity of the Xenon 133 Method for Measurement of Muscle Blood Flow Evaluated by Simultaneous Venous Occlusion Plethysmography

• Intramuscular injection of a small volume of saline containing radioactive, sodium (Na*) was used by Kety for assessing local muscle blood flow. With Xe", a radioactive isotope of the lipophilic inert gas xenon, diffusion equilibrium is better maintained than with the hydrophilic Na* ions, and Xe" clearance studies allow the estimation of local muscle blood flow per unit weight of muscle, e.g...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2002